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Testosterone supplementation partially repaired oxidative damage in ventral prostate epithelia of castrated rats receiving testosterone replacement therapy had a partial decrease in NAD(P)H oxidase expression but an increase in GPx1, SOD2, peroxiredoxin 5 expression, thioredoxin, CAT, glutathione reductase (GR), c-glutamyl transpeptidase, and glutathione synthetase expression in the regenerating ventral prostate tissue

Comparable trials in newly diagnosed Parkinsons disease or relapsingremitting multiple sclerosis could also clarify ASTs disease-modifying potential

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Activating Nrf2 can directly or indirectly transcriptionally upregulate GPX4 expression and cooperatively induce other antioxidant molecules, forming a comprehensive defense network against lipid peroxidation