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An interesting observation was that tumor-bearing rats, which received only vehicle (saline) also presented cognitive deficits

Among various indicators, glutathione reductase (GR), a key enzyme in the oxidative stress process, shows activity changes that can signal hepatocyte metabolic stress and functional abnormalities earlier, providing an important diagnostic window for identifying early liver damage [3]

This data showed that overexpression of Pro1 could produce more -glutamyl phosphate involved in an alternative pathway for a small amount of GSH formation in S

Kinetics of curcumin degradation in aqueous solution

The following reduction of GSH cell concentration and increase of ROS levels also contributes to cell death 88