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p53 has been extensively studied in the context of cancer development, as p53 is the most frequently mutated gene in human cancer and defined as the gatekeeper of cellular fate 68

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PloS One (2013) 8(5):e63276

Other manifestations, such as Marburg disease, Schilders disease and Bals concentric sclerosis are mostly understood as specific variants of those diseases ( As already stated, the clinical differentiation between these diseases occurs through lesion topography, disease course and, in certain cases, as NMOSD and MOGAD, by a biological biomarker

They are also used for patients with rising PSA levels after a surgical/radiation procedure