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Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1

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Using glutamate as an example, and assuming for simplicity that the concentration of glutamate is the same in all neurons, the MRS signal from neuronal glutamate is given by: As seen in the equation, if the fractional volume of the neurons in the voxel decreases due to synaptic loss (or total neuron number loss), the MRS glutamate signal will decrease proportionately