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either those that inhibit haem-iron availability or bacterial acquisition pathways, or toxic haem/iron-mimicking compounds that gain entry to bacterial cells through existing uptake systems ( 5.1.1 Siderophore synthesis inhibitors One of the earliest antimicrobials used for tuberculosis treatment, para-aminosalicylic acid, inhibits synthesis of the bacterial siderophore, mycobactin (Ribeiro and Simes, 2019)