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Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)

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Furthermore, Cyn inhibits the activation of NF-B and microglia, thereby downregulating the proinflammatory cytokines in the hippocampus and reducing neuronal damage in CUMS-induced mice