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PMID: 25857584

When purchasing managers look at APIs for metabolic medicines, knowing these biological differences affects both the treatment plan and the choices made in the supply chain

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This disruption may lead to a progressive decline in ATP production, reduced synaptic transmission efficiency, and disturbances in calcium homeostasis in neurons, thereby exacerbating the central energy deficit and further driving microglial activation, thus potentially completing the vicious cycle (179, 180)

Images were obtained with a Zeiss LSM 710 or 880 confocal microscope