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Drinking plenty of water is key

The ISSN 2017 position stand notes that creatine is safe in healthy kidneys but recommends caution and monitoring in individuals with pre-existing renal conditions 22

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Taken together, these observations suggest that depending on the host species, the tissue of origin and the cytokine signature of the TME, NK cells can be manipulated to acquire a pro-tumoral and pro-angiogenic phenotype