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Consistent with this, a nonsense mutation at the human HDC gene (W317X) has been identified in a family of patients with this syndrome (97, 98) and mice completely deficient in Hdc gene transcription develop a Tourette-like syndrome (97, 99)

doi:10.1186/1743-7075-7-30

Our study indicates the utility of hesperidin to reduce iron-induced oxidative stress in clinical situation

1-carboxyphenyalanine is reported to be associated with poor response to metformin (Naja et al., 2023) and with lower microbiome diversity (Wilmanski et al., 2019), and previously shown to be most discriminating metabolite of insulin resistance (ahin et al., 2022)

Fasting glucose and fasting insulin levels were measured in an independent cohort that included both male and female Gpr146/ and Gpr146/ mice maintained on either standard chow or HFD for 2 months