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Lu W, Pelicano H, Huang P

It was reported that some cancer types are lacking OTC and/or ASS1 expression, so they may be auxotrophic to arginine ( Responses of cancer types sensitive to different therapeutic arginine-depleting agents will be discussed in Tables 2 and 3

The treatment was well tolerated, with no adverse events or clinically meaningful changes observed in vital signs, electrocardiograms, or laboratory biomarkers assessing cardiac, hepatic, renal, thyroid, or metabolic function

Protein N-myristoylation is a ubiquitous cotranslational and posttranslational modification catalyzed by myristoyl-CoA: protein N -myristoyltransferase (NMT), which attaches myristate, a unique 14-carbon saturated fatty acid, to the N-terminal glycine of various eukaryotic and viral proteins