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To test whether this was unique to this single chemotherapy agent, we also repeated the same experimental design in animals that were instead treated with cisplatin (CDDP, 5 mg/kg), which is also associated with ovarian toxicity (Bildik et al, 2015

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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

When you are adequately hydrated, your liver will be able to flush out toxins more effectively

In addition, individual physical factors and the histamine concentration influence the appearance of the symptoms