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The study was published online in the journal Tobacco Control

Moreover, smoking-induced CO exposure leads to endothelial dysfunction and increased oxidative stress, accelerating atherosclerosis and vascular damage

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Based on a true story, the film chronicles the experiences of Jeffrey Wigand (Russell Crowe), a whistleblower who exposes the tobacco industrys dark secrets, and Lowell Bergman (Al Pacino), the investigative journalist from 60 Minutes who helps bring Wigand's revelations to light