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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

However, if you have severe kidney problems, consult with a healthcare professional before proceeding with B12 injections, as excess vitamin levels might not be easily eliminated from your body

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Such patients often are prescribed supplemental B

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