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Proteostasis impairment in protein-misfolding and -aggregation diseases

Your body is essentially running a marathon for forty weeks

Carnitine palmitoyltransferase 1 (CPT 1) is an enzyme located on the outer mitochondrial membrane: it catalyzes the esterification of long chain acyl-coenzyme A to acyl-carnitine

It's what you'd call the body's "master fix-it," making sure our health's in tip-top shape

In RA model, some natural medicines (such as resveratrol, baicalin and -mangiferin) antagonize the transcriptional activity of NF-B by up-regulating the expression of SIRT1, thereby inhibiting the expression of a variety of inflammatory cytokines (such as TNF, IL-6 and IL-1), and inhibiting the proliferation, invasion and migration of FLSs, which has a positive effect on RA