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Seek same-day care if: The rash involves your eyelids, eyes, or the area around your mouth Redness is spreading rapidly beyond the original rash boundaries with warmth and swelling, suggesting bacterial infection Blisters are producing pus or cloudy discharge Fever develops Significant facial or limb swelling occurs The rash covers a large portion of your body surface Prescription-strength oral corticosteroids are the most effective treatment for severe, spreading reactions

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One example where this occurs is when research models in laboratory settings undergo alcohol withdrawal under observation

2014;99(3):E418-426