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10.1007/s00404-026-08331-4 38 KuuG

Biochem Biophys Res Commun 326(3):667669

Thus, it is highly significant that cytosolic GPX1 has been shown to interact with an inactive C145A mutant of M pro , the main cysteine protease of SARS-CoV-2, but not with catalytically active wild-type M pro

Among patients with early TNBC, as in the KEYNOTE-522 trial, neoadjuvant pembrolizumab plus chemotherapy, followed by adjuvant pembrolizumab after surgery, resulted in significantly higher pCR, especially longer EFS and os than neoadjuvant chemotherapy alone

The study also revealed that AS-IV could alleviate iron-dependent cell death in cardiomyocytes by activating the Nrf2 signaling pathway and enhancing the expression of GPx4, thereby attenuating oxidative stress induced by DOX (Luo et al., 2021a)