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Hyperforin, kaempferol, luteolin, and quercetin are the core active ingredients of SJC, Molecular modeling studies further confirmed that AKT1 , caspase 3 ( CASP3 ), IL6 , IL1B , Jun proto-oncogene ( JUN ), MAPK3 , prostaglandin-endoperoxide synthase 2 ( PTGS2 ), TNF , and vascular endothelial growth factor A ( VEGFA ) are the core targets of these four active ingredients, which helped reveal the antidepressant mechanism of SJC [35]

Aim for 1.2 to 1.6 g/kg body weight daily

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ATP levels were determined by measuring fluorescence at Ex/Em = 535/587 nm, using a multi-well plate reader (Synergy H1, BioTek Instruments, Inc., Warsaw, Poland)