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Curran EM, Judy BM, Newton LG, Lubahn DB, Rottinghaus GE, et al

The mouse was returned to the cage and a score was assessed on each bead until 20 min (intact marble = 0, partially buried = 1, buried but visible = 2, completely buried = 3)

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The role of alpha synuclein as a potential target of intracellular oxidants has been demonstrated by identification of posttranslational modifications of synuclein within intracellular aggregates that accumulate in PD brains, as well as the ability of a number of oxidative insults to induce synuclein oligomerization (see, Cole N B., Metal-catalyzed oxidation of alpha synuclein: helping to define the relationship between oligomers, protofilaments and filaments

Aspects of Med