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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores

The clinical development continues with its phase 2 study having already completed enrollment

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Research examines how NNMT inhibition increases NAD+ levels, activates sirtuin longevity pathways, and shifts cellular metabolism from energy storage toward energy expenditure