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For instance, membrane-bound ER receptors, such as ER localize at the cell surface where they regulate cell signaling mediated by ER produced in the CNS

Hamida SB, Plute E, Cosquer B, Kelche C, Jones BC, Cassel JC

That's because it usually is: this kind of pain stems from cellular damage far inside the muscle

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The microvasculature of the kidney has similar functions to the microvascular systems of other organs, including the delivery of sufficient oxygen and nutrients to tissue cells, maintenance of the integrity of the endothelial monolayer, maintenance of the anticoagulant/procoagulant balance, and promotion of leukocyte recruitment (82)