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While this effect is minor in a sealed vial over the short term, refrigeration helps keep the preservative where it belongs: in the solution

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PMID: 12577695

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While voting yes, Christopher Lieu, committee chairperson and director of the Gastrointestinal Medical Oncology Program at the University of Colorado, acknowledged that a positive decision could lead to a slippery slope in terms of the degree of clinical evidence that will be required of future drug applications in similar rare and difficult-to-study indications