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The aggregation of -Syn usually induces protein folding errors, which tends to aggregate into toxic oligomeric compounds, resulting in neurodegeneration in PD patients ( -Syn monomers can result in -Syn oligomers, further aggregating to form -Syn fibers

As we age, our increased susceptibility to disease may partially be attributed to genetic and epigenetic changes that develop over time with continual environmental exposure and damage from endogenous and exogenous reactive oxygen species (ROS)

Overall, this group described a novel two-phase mechanism underlying hyperoxia-induced kidney damage in neonatal mice: an early acute injury phase modulated by renal growth inhibition via activation of IL-6/stat-3 and Smad2 (TGF-) signaling, and a late regenerative stage of accelerated growth leading to impaired glomerular and tubular function