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Brain magnetic resonance imaging and severity of neurological disease in Wilsons disease-the neuroradiological correlations

Here, we report the discovery of a series of fragment hits that bind at the interface between the TRFH domain of TRF1 (TRF1 TRFH ) and a peptide of TIN2 (TIN2 TBM ), an interaction essential for the recruitment of TRF1 to shelterin, using X-ray crystallography (XChem) and ligand-observed NMR (LO-NMR) fragment screening

The GLP-1s are FDA-approved

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The effects are concentration-dependent in ways that arent always linear, so skipping dose-response curves in your model is asking for trouble