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In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors

Some research studies break high homocysteine into three categories: mild (15 to 30 mol/L), moderate (30 to 100 mol/L), and severe (greater than 100 mol/L)

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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions