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Nicotine can also have the following short-term effects: increased muscle activity headache dizziness/light-headedness nausea and vomiting abdominal cramps weakness increased heart rate and blood pressure Using nicotine regularly over a long period of time (usually via cigarettes) is thought to be involved in the development of: high blood pressure periodontitis (gum disease) reduced fertility in men and women male sexual dysfunction rheumatoid arthritis Nicotine use in pregnancy can damage the unborn childs brain and lungs

William and Mary Quarterly (1954) pp: 179-199

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The imposed excise duty is a deterrent against heavy tobacco consumption and sale