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Mechanistically, luteolin activates antioxidant defense pathways, particularly Nrf2-regulated enzymes, while modulating PI3K/AKT signaling involved in granulosa cell survival and metabolic support of the oocyte (Pan et al., 2025)

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Erastin, a specific small-molecule inducer of ferroptosis, was named in the work where this non-apoptotic mode of cell death was initially reported

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