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A meta-analysis showed that intravitreal administration of ranibizumab was associated with systemic vascular adverse events, including embolic eventsstroke and myocardial infarction (Sultana and Scondotto 2020)

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During treatment, close monitoring of clinical, urine volume, and laboratory parameters is recommended to prevent overcorrection, which can lead to osmotic demyelination syndrome (ODS) 10

(2) People with certain medical conditions: Due to DSIP's effects on hormone regulation, individuals with Cushing's syndrome or uncontrolled hypertension should avoid use