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In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus

1), suggesting that in such culture conditions, the TSS pathway is active, and CBS contributes to the regulation of cysteine biosynthesis

BG: Conceptualization, Supervision, Validation, Writing original draft, Writing review & editing

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Consequently, the quantitative strength of a molecules reactivity with glutathione (GSH) is a frequently used indicator of its toxicity