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People with soft-tissue injuries affecting their tendons, ligaments, or muscles are the most likely candidates

Preclinical Toxicology: Toxicity studies in rodents indicate that even high doses (e.g., 20 mg/kg) do not result in gross organ toxicity or lethality in the acute setting

For signal detection, the ABI Prism 7700 sequence detector (Life Technologies, CA, USA) was programmed to execute an initial step of 2 min at 50C and 10 min at 95C, followed by 40 thermal cycles of 15 sec at 95C and 1 min at 60C

Specifies the full suite of in vitro tests spray content uniformity, droplet size distribution, spray pattern, plume geometry, drug particle size and the statistical framework (Population Bioequivalence, PBE analysis) for demonstrating equivalence

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