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doi: 10.1016/S0006-291X(03)01385-8

The change in the melting temperature (T m ) for the bound and unbound states is greater than 15 C

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Nishida K, Kang JD, Gilbertson LG, Moon SH, Suh JK, Vogt MT, Robbins PD, Evans CH: Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene

Two hours after dosing, the severity of headaches decreased in both groups