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Our findings provide a more comprehensive understanding of the FQ persistence mechanism, confirming that the H 2 O 2 detoxification systemcomprising the GpoA, TpxD and AhpD peroxidasesis critical for pneumococcal survival under lethal FQ concentrations

The pooled analysis estimates a statistically significant reduction of approximately 1.23 mol/L (McRae, 2013)

doi: 10.3389/fimmu.2020.01467 94 GadanecL

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