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Michael Pagliassotti, a Colorado State University biochemist who did many of the relevant animal studies in the late 1990s, says these changes can happen in as little as a week if the animals are fed sugar or fructose in huge amounts 60 or 70 percent of the calories in their diets

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Even as safer alternatives to smoking deliver some of the most promising population-level health gains in decades, they face fierce and sometimes irrational pushback from groups who insistdespite overwhelming evidence to the contrary that abstinence alone is the only acceptable path