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If any of the following happen, tell your nurse immediately: Chest tightness, shortness of breath, or wheezing Hives or swelling of the lips or tongue Severe back or abdominal pain Intense pain, swelling, skin coolness, blanching, or burning at the IV site (signs of infiltration , where fluid leaks into surrounding tissue) A quality provider keeps emergency medications, oxygen, and clear EMS escalation protocols available for exactly this reason

Zhou N, Hofstetter WL, Mitchell KG, Bayley EM, Ajani JA, Antonoff MB, Betancourt SL, Blum-Murphy M, Feldman HA, Lin SH, Maru DM, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Weston BR

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P.CaldanaC.MehrniaM.et al (2010)