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Most of it breaks down in the stomach before reaching your cells

Clearance is the most important pharmacokinetic parameter because it is the only parameter that controls overall drug exposure and it is used to calculate the dosage required to maintain a specific average steady-state concentration

(PubMed) Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K

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This review discusses the molecular mechanisms underlying inflammation and oxidative stress in OP, highlights current therapeutic approaches, and proposes future research directions aimed at improving the prevention and treatment of osteoporosis