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After the substrate is ubiquitinated, competitive binding of the ubiquitin receptor to the proteasome and ATG8 determines whether the substrate is degraded via UPS or ALS

206 208 Although Caspase-3 is a pro-apoptotic caspase, existing evidence shows that after treatment with chemotherapy drugs, GSDME can be cleaved and activated by caspase-3, leading to pyroptosis

Youll also need to check another couple of boxes on this form, corresponding with your 1099-DA forms (or use tax software that'll do it for you)