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Upon ligand binding, this presumably membrane-bound receptor transduces intracellular chemical/redox signals that relay messages for the regulation of gene expression, a phenomenon mainly involving the activation of transcription factors [2, 13, 14, 1618, 26, 34, 51, 70]

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Her studies show that genetic risk for diseases like Alzheimers is concentrated not in protein-coding genes, but in regulatory regions of the genome, epigenetic switches that control immune behavior in the brain

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Immunity 16 , 769777 (2002)