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Potential synergy with peptides related to the regulation of the GH/IGF-1 axis is discussed

4 Discussion The protective mechanism of polyphenols against cisplatin ototoxicity is mainly to build two major protective barriers in normal tissues

Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig