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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

Sep 2022;31(3):567-578

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The Ovarian-Adrenal-Thyroid axis in women and the Adrenal-Thyroid axis in men are particularly important