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Before elective orthopaedic surgery, it is recommended to discontinue GLP-1 medications as they can delay gastric emptying and increase aspiration risk during anesthesia

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There is also a very safe profile (lethal dose (LD1) could be not achieved) [84], a point recently confirmed in a large study conducted by Xu and collaborators [85]

Pregnancy and breastfeeding should be considered absolute contraindications due to unknown effects on fetal development

52 Individuals who carry two copies of the apolipoprotein E (APOE)e4 gene are at increased risk of developing ARIA