It has also been described that curcumin, as well as other bioactive phytochemical with similar structures at concentrations between 50 and 500 M, can specifically inhibit HDACs both at the level of activity and expression
Rheumatol Ther 4(2):247261 Rezaei H, Saevarsdottir S, Geborek P, Petersson IF, van Vollenhoven RF, Forslind K (2013) Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis: results from the SWEFOT trial
Interestingly, while GSH declines in fibrosis, cysteine levels are elevated, suggesting that reduced GSH is primarily due to enzyme dysfunction rather than substrate deficiency [123]
Can glutathione support weight loss
NAC supports ongoing synthesis and tends to be more cost-effective for long-term use