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Sales of the therapy reached about $36.5 billion in 2025 , surpassing semaglutide and positioning it as one of the world's top-selling pharmaceuticals

Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

The most common side effects were adverse skin reactions (16/389, 4.1%), gastrointestinal problems (14/389, 3.6%), skin hyperpigmentation (7/389, 1.8%), and headaches (5/389, 1.2%)

Before advanced investigations begin, researchers often perform analytical review and characterization studies

For most gut health use cases, the combination delivers what neither peptide can alone