igf-1 lr3 insulin-like growth factor research IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty Insulin-like growth factor-1 deficiency and

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doi: 10.1016/j.mayocp.2019.02.018 43 MosegaardSDipaceGBrossPCarlsenJGregersenNOlsenRKJ

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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]