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The injectable form was placed on the FDA's Category 2 bulk drug substances list in 2023, restricting compounding pharmacies from preparing it under Section 503A

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Andreadis P, Karagiannis T, Malandris K, et al

The key mediators and effectors of the adaptogenic activity of adaptogens are CRH [197], cortisol [27,198,202,203,204], neuropeptide Y, molecular chaperones Hsp70, stress-activated protein JNK [27], monoamines [204,205,206,207], and melatonin [67]

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