PMID: 94
Virginia tobacco, which has a sweet and mild taste, or burley tobacco, which has a stronger taste, is usually used in hand-rolled cigarettes

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Limitations A major limitation to concluding the current body of research on the cancer-related effects of e-cigarette use is the fact that, compared to other health effects, there is a lack of published studies on this topic
About one third of the tobacco cultivated in the U.S