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Main pathway: G-actin sequestration Native T4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 M, controlling the pool of free actin available for polymerization into F-actin (actin filaments)

This complex consists of core subunits ( Paf1 , Leo1 , Cdc73 , Rtf1 , and Ctr9 ) and a unique subunit specific to humans ( Ski8 )

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Biochimica et Biophysica Acta (BBA) 1869(6):166724

Alterations in external conditionssuch as dietary factors, chemical exposures, and psychological stressorsor cellular stress can induce changes in epigenetic marks, leading to gene transcription activation or silencing