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Numerous microbial species that may produce neurotransmitters, signaling chemicals, or metabolize their precursors into various substances can be found in the human microbiome (163165), during food fermentation and bacterially altered host molecules including bile acids (BAs) (166), tryptophan metabolites, and SCFAs with CNS effects are also produced by the gut bacteria

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DSIP Research and Metabolism Studies in laboratory animals suggest that DSIP interacts with central opioid receptors in producing its analgesic-like properties

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