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Under normoxic conditions, the proline residue of HIF1 is hydroxylated

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Subcutaneous administration is an alternative for self-injecting patients

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The main chain of a valine/leucine/isoleucine/threonine residue that precedes the conserved cis -proline is hydrogen-bonded to the backbone of CysGS (cysteine residue of glutathione) (Figure 3A)

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