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The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1
Adequate supply of BPC-157 is important not only for the effectiveness of the substance, but also to minimize the risk of side effects
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Biochem Pharmacol 63:30520, PMID: 11841806 Haddad JJ (2011) A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium