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The levels of SIRT6 were found to be elevated in the synovial tissue of smokers with RA and in the joints of mice exposed to cigarette smoke

Cirelli et al

Geng 2013

Knock-down of Nrf2 by siNFE2L2 slightly decreases Nrf2-GFP, Keap1-GFP and Srxn1-GFP base levels

In one study looking at the impact of NAC on noise-induced hearing loss, taking 1,200 mg per day for 14 days led to a significant reduction of noise-induced temporary threshold shift