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Examples of such environments are microvessels with diameters smaller than the size of tumor cells [146], narrow (~ 15 m-sized) gaps between endothelial cells [147], micropores with diameters ranging from 1 to 20 m [148], ECM fibers [149], and longitudinal, channel-like tracks with widths ranging from 3 to 30 m [150]

Patients should also pay attention to other symptoms that accompany fatigue, such as dizziness, confusion, or palpitations, and seek medical advice promptly if these occur

The treatment with folic acid should be combined with pyridoxine in vitamin B 6 -deficient patients who are responders to an oral methionine load